Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2
نویسندگان
چکیده
منابع مشابه
IgE-mediated anaphylactic degranulation of isolated human skin mast cells.
Isolated human skin mast cells (HSMC) were prepared and cultured overnight before functional and electron microscopic studies. Mast cell suspensions were examined after stimulation with anti-IgE to produce anaphylactic degranulation or examined in buffer-incubated controls. Histamine release was measured in replicate samples. Control, isolated HSMC studied by electron microscopy were well prese...
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The neuromedin U (NMU) system is composed of NMU, neuromedin S (NMS) and their receptors NMUR1 and NMUR2. This system is involved in the regulation of energy homeostasis, neuroendocrine functions, immune response, circadian rhythm and spermatogenesis. The present study aimed to investigate the possible role of the NMU system in regulating functions of cultured rat calvarial osteoblast-like (ROB...
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Neuromedin U (NMU) is a neuropeptide that is expressed in the gastrointestinal tract and central nervous system. NMU interacts with two G protein-coupled receptors, NMU-R1 and NMU-R2. Whereas NMU-R2 localizes predominantly to nerve cells, NMU-R1 is expressed in peripheral tissues including lymphocytes and monocytes, suggesting a role of NMU in immunoregulation. However, the functions of NMU in ...
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In severe hypercholesterolemia and sometimes even in normolipemia, lipoprotein-derived cholesterol accumulates in the skin, forming xanthomas, but the local factors triggering this accumulation are not known. We therefore studied the effect of immunoglobulin E (IgE)-mediated stimulation of cutaneous mast cells on the transport of low density lipoprotein (LDL) from plasma to skin during the pass...
متن کاملEpidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation
Although keratinocyte-derived neuropeptide neuromedin U (NMU) mediates the proinflammatory effects of innate-type mast cell activation, no information is available on the physiological roles. Here, to investigate the effects of NMU on IgE-mediated allergic skin inflammation, we determined whether IgE-mediated inflammation associated with severe scratching was induced in Nmu-/- mice administered...
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ژورنال
عنوان ژورنال: Allergy
سال: 2018
ISSN: 0105-4538
DOI: 10.1111/all.13555